INTRODUCTION
Biochips were
invented 9 years
ago by gene scientist Stephen Fodor . In a flash of light he saw that
photolithography, the process used to etch semi conductor circuits in to
silicon could also be used to assemble
particular DNA molecules on a chip.
The
human body is the
next biggest target
of chip makers
. medical researchers have
been working since
a long period
to integrate humans body
and chips . In
no time or
at maximum within
a short period
of time Biochips
can get implanted
into the body
of humans . So
integration of humans
and chips is
achieved this way .
Money
and research has
already gone into
this area of
technology .Anyway such
implants are already
being experimented with
animals .
DEFINITION:-
A biochip
is a collection
of miniaturized test
sites (microarrays)
Arranged
on a solid
substrate that permits
many tests to be
performed
At
the same time
inorder to achieve
higher throughput and
speed .
Typically a biochips
surface is no larger
than a finger
nail . Like
A
computer chip that
can perform millions
of mathematical operations
In
one second , a biochip
can perform thousands
of biological reactions
Such
as decoding genes , in
a few seconds
.
A genetic
biochip is designed to
“freeze” into place the
structures of many
short strands of DNA
( deoxyribo nucleic acid )
, the basic
chemical instruction that
determines the characterstics of an organism
. effectively , it is
used as a
kind of “ test tube
“ for real
chemical samples. A
specially designed microscope
can determine where
the sample hybridised
with DNA strands in
the biochip.
IN WHAT WAY THEY WORK:-
The chips
are of the
size of an
uncooked grain of
rice small enough
to be injected
under the skin
using a syringe needle
. They respond
to a signal
from the detector
, held just
a few feet
away by transmitting
an identification number
. This number is
then compared with
a database listing
of registered pets .
GETTING
UNDER THE SKIN :-
Hausdorffs
chips are external
, but another
chip currently under
development will be
injected under skin .
The chips will
allow diabetics to
monitor the level
of sugar glucose
in their blood . Diabetics currently
use a skin
prick and a
handheld blood test
and then medicate
themselves with insulin , depending
on the result
. The system
is simple and
works well , but
drawing blood each
time is pain full
so patients donot
test themselves as
often as it
is needed .
THE S4MS CHIP:-
The new
s4ms chip will
get underneath the
skin sense the
glucose level and
send the result
back by radio
frequency communication. A light
emitting diode starts
of the detection
process . The light that
it produces hits
a fluorescent chemical :
one that absorbs
incoming light and re
emits it at a
longer wavelength . The longer
wavelength of light is
then detected , and the result is
sent to a
control panel outside the body . Glucose is detected, because the sugar
reduces the amount of light that the florescent chemical re emits . the more glucose there is the less light that is detected.
S4MS
is still developing the perfect
fluorescent chemical, but the key design innovation of the S4MS chip has been
fully worked out. The idea is simple : the LED
is sitting in a sea of the fluorescent molecules. In most detectors the
light source is far away from the fluorescent molecules, and the inefficiencies
that come with that mean more power and larger devices. The prototype S4MS chip
22mW LED, almost 40 times less powerful than the tiny power on buttons
on a computer keyboard. The low power requirements mean that energy can be
supplied from the outside, by the process called induction. The fluorescent
detection itself does not consume any chemicals or proteins, so the device is
self – sustaining.
BIOCHIPS USED TO
DETECT AND MONITOR DISEASES:-
CHIPS THAT FOLLOW
FOOT STEPS : -
The civil debate over
biochips has obscured
their more ethically
benign and medically
useful applications .
Jeffery housdoff of the Beth
Israel deaconess medical
center in Boston
has used the
type of pressure
sensitive resistors found
in the buttons of a
microwave oven as
stride timers .He places
one sensor in the
heel of a
shoe and other
in the ankle
and adds a
computer to the
ankle to calculate
the duration of
each stride(step).
Young healthy
people can regulate
the duration of
each step very
accurately , but elderly
patients prone to
frequent falls have
extremely variable stride
times . by using this
information doctors can
change their medication
and ask them
to do exercises .
Hausdorff is also
is also using
the system to
determine the success
of treatment of
congestive heart failure
. By monitoring
the number of
strides that a
person takes , he
can directly measure
the patients activity
level , by passing
the often flawed
estimate made by
patient .
Oxy sensors
The
working model of an oxygen sensor uses
the same layout. With its current circuitry it is about the size of a large
shirt button, but the final silicon wafer will be less than a millimeter
square. The oxygen sensor will be useful not only to monitor breathing in the
intensive care units, but also to check that packages of food or containers of
semi conductors stored under nitrogen gas, remain air tight.
Another
version of an oxygen sensing chip currently under development sends like pulses
out into the body. The light is absorbed
to varying extends, depending on how much oxygen is being carried in the
blood, and this chip detects the light that is left. The rushes of blood pumped
by the heart or also detected, so the same chip is pulse monitor. The number of
companies already make large scale versions of such detectors.
This
oxygen chip is perhaps about two years away, but the dimensions of another
temperature – sensing chip has been reduced to 3mm per side. The transition of
certain semi conductors to their conducting state is inherently sensitive to
temperature, so designing the sensor was simple enough. With some miniature
radio frequency transmitters, and foam rubber earplugs to hold the chip in
place, the device is complete. Applications range from sick children, to
chemotherapy patience who can be plagued by sudden raises in body temperature
in response to their anti cancer drugs.
Brain Surgery with an on off switch
Sensing and measuring is one thing,
but can we switch the body on and off? Heart pace makers use the crude approach
: large jolts of electricity to synchronize the pumping of the heart. The
electric pulses of the Activa implant,
made by US – based medtronics or directed not at the heart but the brain, they
turn off brain signals that cause the uncontrolled movements, or tremors,
associated with diseases such as
Parkinson’s.
Drug therapy for Parkinson’s disease
aims to replace the brain messenger, dopamine, the product of the brain cells
that are dying. But eventually that drugs affects wear off, and the erratic
movements come charging back.
The activa implant , cleared for use in the US in AUG, 1997 is a
new alternative that users high frequency electrical pulses to reversibly shut
off the thalamus. The implementation surgery is far less traumatic than
thalamotony
And if there are
any post operative problems the stimulator can simply be turned off. The implant primarily interferes with
aberrant brain functioning.
Adding Sound To Life
The most ambitious bio engineers are today trying to add back brain
functions, restoring sight and sound where there was darkness and silence.
The success
story in this field is the cochlear implant. Most hearing aids are
Glorified
amplifiers, but the cochlear implant is for patients who have lost the hair
cells that detect sound waves. For these
individuals no amount of amplification is enough.
The cochlear implant delivers
electrical pulses directly to the nerve cells
In the cochlea,
the spiral-shaped structure that translates sound into nerve pulses. In normal hearing individuals, sound waves
set up vibrations in the walls of the cochlea, and hair cells detect these vibrations.
High frequency noises ( deep notes) vibrate the base of the cochlea,
while low frequency notes vibrate nearer the top of the spiral. The implant mimics the job of the hair
cells. It splits the frequencies of
incoming noises into a number of channels ( typically eight)
And then
stimulates the appropriate part of the cochlea.
‘Clarion
‘ and ‘Nucleus’
the two most successful cochlear
implants are the clarion ( developed at the university of California at San
Francisco (UCSF) and Advanced Bionics Corporation of Sylmar in California) and the Nucleus ( developed at the University
of Melbourne,Australis, and made by cochlear of Sydney, Australia).
Upgrades largely
focus on improving the speech processing software, which is operated by a
minicomputer worn on the patient’s belt.
Theoretically, increasing the number of channels( and electrodes) could
improve sound perception.
But speech is
perceived in an area of the cochlea only 14mm long, and spacing the electrodes
too close to each other causes signals to bleed from one channel to another.
The result is a broad brush version
of hearing.while some recipients of the devices report speech like sounds,many
characterise their new world as being populated with quacking ducks or banging
garbage cans. But the success is undeniable.currently two thirds to three
quarters of patients (with more recent models) can understand speech without lip reading says Steve Rebscher,a
member of UCSF team.”its pretty amazing
, and certainly better than a lot of people anticipated these devices would
do”.
EXPERIMENTS
WITH LOST SIGHT:-
With the ear
atleast partially conquered , the next logical target is the eye. Several
groups are working on implantable chips that mimic the action of photo
receptors , the light sensing cells at the back of the eye. Photo receptors are
lost in retinitis pigmentosa , a genetic disease,and in age related macular
degeneration , the most common cause of lost sight in the developed world. Joseph Rizzo of the
Massachusetts eye and ear infirmary , and john Wyatt of the Massachusetts institute of technology have made a twenty
electrode,1mm square chip,and implanted it at the back of rabbits eyes.
The original chip,the thickness of
human hair,put too much stress on the eyes the new version is ten times
thinner. The final set up will include a fancy camera mounted on a pair of
glasses.The camera will detect and encode the scene,then send it in to the eye
as a ;laser pulse,with the laser also providing the energy to drive the chip.
Rizzo has confirmed that his tiny
array of light receivers(photo diodes) can generate enough electricity to run
the chip.He has also found that the amount of electricity needed to fire a
nerve cell into action is about hundred fold lower in the eye than in the
ear,so the currents can be smaller,and the electrodes more closely spaced.
For now,the power supply comes from a
wire inserted directly into the eye and ,using this device , Rizzo has detected
signals reaching the brain. Eugene de Juan of Johns Hopkins Wilmer eye
Institute is trying to answer that question by using human subjects.His
electrodes , inserted directly in to the eye , are large and some what crude
.But his results have been startling . Completely blind patients have seen well
defined flashes, which change in position and brightness as De Juan changes the
position of the electrode for the amount of current.
In his most recent experiments ,
patients have identified simple shapes out lined by multiple electrodes . With
as little as an 8x8 array , de Juan believes he could approximate character
recognition, and a 25x25 array might give a crude image.
The big money in eye implant is in
Germany , where the government has pledged
millions of US$.One is similar to the US projects in which chips are
implanted on the surface of the retina,the structure at the back of the eye.the
other project is putting its implants at the back of the retina where the photo
receptors are normally found.These “subretinal”
chips may block the transport of oxygen and food to the overlying nerve
cells, so Everhart Zrenner of the
university of Tubinger of Germany is developing
‘chain mail’ electrode arrays, with plenty of holes for the delivery of
supplies.
FENDING OFF DRUG RESISTANT TB STRAINS WITH BIOCHIP TECHNOLOGY:-
As tuberculosis threatens to
make its come back shrouded in a drug
resistent form ,a new biochip technology developed by Argonne National
Laboratory and the Russian Academy of Sciences’ Englehardt Institute of Microbiology, may help stem a
global epidemic.
In October, Argonne will
begin testing its biochip’s ability to distinguish between different TB
strains.l The tests will be done on harmless segments of genetic material
removed from TB bacteria.
The biochips are designed to
carry out thousands of biochemical reactions simultaneously, and have performed
well in laboratory tests. “But this will be their first test in the realm of real-world medical diagnostics.
They chose TB for the test
because new drug resistant strains have
sprung up in Russia and can easily spread to the whole world, including US.If
they can quickly identify specific strains, it will help doctors prescribe the
best
Treatments
quickly and possibly help prevent a world wide academic.
According to World Health
Organization, TB kills more youth and adults than any other infectious disease,
including AIDS and malaria combined.
Every year, 7 to 8 million people become sick
with the disease.
Today, TB patients are
often prescribed several antibiotics simultaneously because it takes weeks or
months to identify specific TB strains, and patients can die during this time.
“If our biochip can do the job,” “physicians can prescribe the most effective
treatment without delay.”
If successful, these
initial studies will set the precedent for similar evaluations of other
bacterial and viral diseases.
DRUG-RESISTANT TB
Antibiotic resistance
results from the natural selection of stronger bacteria over weaker ones. Stronger bacteria have mutated
genes that confer antibiotic resistance.
Because TB cells grow
slowly,antiobiotics must be taken daily
for atleast six months to ensure that all the bacteria are eliminated.If
treatment is shortened or inconsistent,
surviving bacteria-those most resistant to the treatment-can reproduce, passing
their resistance on to their offspring.
In impoverished nations,
where people cannot afford months of medication, victims effectively become
incubation chambers for new drug-resistant strains. In some Russian
institutions, roughly 80 percent of the TB patients were found resistant to
atleast one antibiotic, and 50 percent showed multiple resistance.
Although airborne, TB is
not remarkably contagious compared to other viral and bacterial infections.
With only one exposure, the body’s defenses normally keep the bacteria at bay,
unless the immune system is weakened by a disease such as AIDS. However,with
continued exposure, as when living with a person with active TB, someone can
develop the disease quickly.
BETTER, CHEAPER, FASTER
Like computer chips, which
perform millions of mathematical operations a second, Biochips can perform
thousands of biological reactions in a few
seconds.
The Argonne/Englehardt
biochip is essentially a glass side containing up to 10,000 tiny gel pads, each
serving as a mini test-tube. Attached to
each gel pad is a short strand of DNA, the unique set of blueprints that determine
the building blocks of every living species. The information in DNA is encoded
in long sequences of four molecular units, or bases – adenine(A), cytosine(C),
guanine(G) and thymine(T). The precise pairing of A on one strand with T on
another strand and G with C, allows DNA to form it’s “double helix”.
By fixing only one
strand of the double helix to each gel pad, the
chip employs the natural tendency of each DNA base to pair with it’s
complementary base. When tests begin, a sample of unknown single strands of TB
DNA will be spread on a chip and allowed to naturally pair up with single
strands of known TB DNA already in the gels. A direct match will identify drug
resistant TB strains.
By changing the DNA samples in the gels, scientists can
also use this technique to diagnose a
unlimited range of other diseases quickly and efficiently.
One of the biggest
advantages of Argonne’s Biochips, over
conventional Biochips, is that they can
be cleansed and reused up to 50 times, making them more economical than
conventional biochip technology . Also, the gel’s greater size allows them to
hold up to 1,000 times the material, making them more sensitive than any other
biochip.
In standard TB
diagnostics, a patient must endure a number of tests. First, a skin test is
done to determine if they had ever been exposed. Second, a chest X-ray is done
to determine if TB has damaged any lung tissue. Finally, a throat culture is
done to determine if the TB is still growing and what antibiotics it resists.
Results from the throat culture alone can take a month.
“With the advanced
biochip technology, we’d be able to get all information we need in a couple of
hours”, “Without any false positives.”
EVIDENCE OF SUCCESS
The researchers have
reason for being optimistic about this project. “The fact that it has worked in
one sample and it wasn’t difficult to perform, shows us that this has a lot of
potential,” . “The current round of tests will tell us more.”
However, bringing
the test into the clinical setting is another giant leap. “We’re using DNA ,
not actual fluid from patients,” “But it does give us a good idea of the
direction we want to go.”
If successful, they
would move to a larger scale study with more patients and more conditions and
then try to get it to work using fluid samples from active TB patients.
“We’ll be doing a
full scale clinical diagnosis bit it’ll take years to get to the market,”
“Considering that TB is becoming a global epidemic, some urgent steps must be
taken to speed up the process. The first step is to figure out if this has a
chance to work.”
Implantable Biochips and The End of Human Freedom and
Dignity exposes the government plot to wield this
invasive, life destroying technology.
Texe Marrs quotes an executive officer of the World Future Society (
27,000 influential members) as saying : “A biochip
implant could be used in a variety of human applications… A number could be
assigned at birth and follow that person throughout life ..It would be
implanted on the back of the right or left hand so that it would be easy to
scan at stores. The biochip implant could also be used as a universal type of
identification card”.
A top White
House official addressing a high tech conference sponsored by IBM, stated :
“The smart card is a wonderful idea, but even better would be a chip in your
ear.. We need to go beyond the narrow conceptualization of the smart card and
really use some of the technology that’s out there”.
Science News, an authoritative
scientific journal, reports that, “New electronic techniques have been
developed to eavesdrop on the brain. The
technique allows outsiders to influence the person’s brain cell conversations
and to talk directly with the individual’s brain neurons”.
The Wall Street Journal says that a
U.S. Naval research laboratory, funded by intelligence agencies, is now able to
unite living brain cells with microchips.;
some authorities fear that the Defense Departments intend to produce an “army killer zombies !” One army expert
alarmingly calls the new biochip implant a “Frankenstein _ type weapon”.
TRULY EMBEDDED CHIPS:-
Media Medical And Industrial
Complex had a long term plan to implant subcutaneous microprocessor for a
variety of help , entertainment and
communication purposes by
acclimating a generation of prospective customers
to such skin
altering
conditions.companies are seeding
the market for
their future offerings.
This is
the stuff of
science fiction,but serious
medical researchers are
developing chips with
tiny doses of
medication that can
be dispensed automatically,without the
patient having to
measure a dose
or remember to
take it at
regular intervals.
The recent
attention to bioinformatics rekindles
the imagination about
where such blend
of bioscience and
infotechnology may take
us. Adrenaline and BMSG will
provide a due
diligence service for
investors and biotech
companies ,offering independent
analysis of ventures
into bioinformatics,which they
define as the
art and science
of using computational
tools to find
answers to biological
questions.In other words
they are looking
at near term
projects such as
Genome and Molecular
biology research as
well as individualized
medicine.Their collaborative work
will help scientists
and it professionals
use data mining
and knowledge management
and process management to
investigate biological frontiers. Vital stepping
stones but not
wondrous or delicious
as the future
potential applications of
bioinfotech.
Looking future
ahead when implanted
chips are programmed
with
telecommunications capability
they can open
new connectivity and
entertainment options . Preserving that the
first chips are
‘receive only’.They would
become the ultimate
pagers : delivering a
unification or internal
‘ping’ directly to
human neurons.
Eventually entertainment
providers will begin to exploit
this capability ,sending
music or visceral experiences directly
through chip.some programming
may be tied
to video shows
, giving you the
mosh-pit experiences while
watching MTV or
feeling the polar
freeze while a
discovery documentary about
Antarctica.More probably porn
merchants will be the first
to capitalize on such
in body experiences.So that watching
a playboy channel show could
also trigger the
appropriate internal response among chip
equipped viewers.
Later the implemented
microprocessor will be
upgraded to two way
capacity transmitting internal
data back in the appropriate network
through a wireless
feed.The medical monitoring
opportunities are immense
but so are
the tracking capabilities.It is the
ultimate loss of personal privacy
when your body
is sending signals
about where you
are and what
you are sending.?
Several
other roots towards
bioinfotech connection are
already being followed.Predictive network
of Cambridge is
developing biometric system
used to identify
which individuals interface
with computer and
media devices.Predictive networks
is monitoring personal
usage patterns (how
individuals use specific
keys and buttons
,including the speed
and measure of finger close) to
identify and categorize
customer.Although it’s a major
leap from such tracking
of external behaviors
to inserting a microprocessor under
the skin, the
eventual outcome could
be the same:data gathering and
response based on
physical connection and
the response.
Bio-infotech seems
to be a
promising sector for the region-even across-river
opportunity that would
combine the bio-medical
resources in Mary land
with the Infotech strengths of
Virginia .
ADVANTAGES OF BIOCHIPS:-
1.
TO RESCUE
THE SICK
2. TO FIND LOST PEOPLE.
3. TO LOCATE
DOWNED CHILDREN AND WANDERING ALZHEIMER’S
PATIENTS.
4.TO IDENTIFY
PERSON UNIQUELY.
5. THEY
CAN PERFORM THOUSANDS OF
BIOLOGICAL REACTIONS
OPERATIONS IN FEW SECONDS.
6. IN MONITORING HEALTH CONDITION OF INDIVIDUALS
IN WHICH THEY
ARE SPECIFICALLY EMPLOYED.
7. THEY CAN
PERFORM THOUSANDS OF
BIOCHEMICAL REACTIONS.
SIMULTANEOUSLY.
CONCLUSION
If people feel that they loose their privacy because of Biochips, they may resist use of it.But if they feel that it could help in a lot of ways like detecting,minitoring and curing of diseases they can use them intensively.
So it is users of chip who determine its future .
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